Pub. Date : 2015 Jan 27
PMID : 25544544
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show herein that the ligand binding domains (LBD) of the GluN1 and GluN2A subunits of the NMDAR heterodimerize only when both coagonists, Glu and Gly/d-Ser, bind to their respective sites on GluN2 and GluN1. | Glycine | glutamate ionotropic receptor NMDA type subunit 1 | Homo sapiens |
| 2 | We show herein that the ligand binding domains (LBD) of the GluN1 and GluN2A subunits of the NMDAR heterodimerize only when both coagonists, Glu and Gly/d-Ser, bind to their respective sites on GluN2 and GluN1. | Glycine | glutamate ionotropic receptor NMDA type subunit 1 | Homo sapiens |
| 3 | Also, in a heteromer formed by the LBDs, GluN2A is more sensitized to bind Glu, while the affinity of Gly for GluN1 remains unchanged. | Glycine | glutamate ionotropic receptor NMDA type subunit 1 | Homo sapiens |