Title : Fexofenadine regulates nuclear factor-κB signaling and endoplasmic reticulum stress in intestinal epithelial cells and ameliorates acute and chronic colitis in mice.

Pub. Date : 2015 Mar

PMID : 25538104






2 Functional Relationships(s)
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1 In addition, the induction of ER stress markers caspase-12 and p-eukaryotic initiation factor 2 (eIF2)-alpha was significantly suppressed by the pretreatment of fexofenadine. fexofenadine caspase 12 Mus musculus
2 Finally, fexofenadine significantly reduced the severity of colitis and the immunoreactivity of caspase-12 and p-eIF2-alpha in IL-10(-/-) mice as compared with controls. fexofenadine caspase 12 Mus musculus