Title : A sensitive and microscale method for drug screening combining affinity probes and single molecule fluorescence correlation spectroscopy.

Pub. Date : 2015 Feb 21

PMID : 25526365






2 Functional Relationships(s)
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1 Then, the dasatinib derivatives were synthesized and labeled with the fluorescent dye Alexa 488, and the binding and dissociation processes of Alexa 488-dasatinib and ABL1 were systematically investigated. Dasatinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
2 The dissociation constant and the dissociation rate for the Alexa 488-dasatinib-ABL1 complex were determined. Dasatinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens