Pub. Date : 2015 Apr
PMID : 25521524
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | KEY RESULTS: The supraspinal antinociceptive effects of oxycodone, but not morphine, were abolished by blocking G protein-gated inwardly rectifying potassium1 (Kir 3.1) channels. | Oxycodone | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 2 | Following treatment with oxycodone and morphine, IPSCs were reduced in the FBC model, and the inhibition of presynaptic GABA release by oxycodone, but not morphine was enhanced and dependent on Kir 3.1 channels. | Oxycodone | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 3 | Following treatment with oxycodone and morphine, IPSCs were reduced in the FBC model, and the inhibition of presynaptic GABA release by oxycodone, but not morphine was enhanced and dependent on Kir 3.1 channels. | Oxycodone | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 4 | CONCLUSION AND IMPLICATIONS: Our results demonstrate that Kir 3.1 channels are important for supraspinal antinociception and presynaptic GABA release inhibition by oxycodone in the FBC model. | Oxycodone | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |
| 5 | Enhanced GABAergic synaptic transmission at VLPAG neurons in the FBC model is an important site of supraspinal antinociception by oxycodone via Kir 3.1 channel activation. | Oxycodone | potassium inwardly rectifying channel subfamily J member 3 | Homo sapiens |