Title : Transcriptomic signatures of peroxisome proliferator-activated receptor ╬▒ (PPAR╬▒) in different mouse liver models identify novel aspects of its biology.

Pub. Date : 2014 Dec 15

PMID : 25511156






3 Functional Relationships(s)
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1 The aim was to obtain a comprehensive view of common and model-specific PPARalpha-dependent genes and biological processes to understand the impact of cross-talk between parenchymal and non-parenchymal fractions as well as the effect of inter-organ interactions on the hepatic PPARalpha transcriptome.To this end we analyzed microarray data of experiments performed in mouse primary hepatocytes treated with the PPARalpha agonist Wy14643 for 6 or 24 h (in vitro), mouse precision cut liver slices treated with Wy14643 for 24 h (ex vivo), and livers of wild type and Ppara knockout mice treated with Wy14643 for 6 h or 5 days (in vivo). pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus
2 The aim was to obtain a comprehensive view of common and model-specific PPARalpha-dependent genes and biological processes to understand the impact of cross-talk between parenchymal and non-parenchymal fractions as well as the effect of inter-organ interactions on the hepatic PPARalpha transcriptome.To this end we analyzed microarray data of experiments performed in mouse primary hepatocytes treated with the PPARalpha agonist Wy14643 for 6 or 24 h (in vitro), mouse precision cut liver slices treated with Wy14643 for 24 h (ex vivo), and livers of wild type and Ppara knockout mice treated with Wy14643 for 6 h or 5 days (in vivo). pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus
3 The aim was to obtain a comprehensive view of common and model-specific PPARalpha-dependent genes and biological processes to understand the impact of cross-talk between parenchymal and non-parenchymal fractions as well as the effect of inter-organ interactions on the hepatic PPARalpha transcriptome.To this end we analyzed microarray data of experiments performed in mouse primary hepatocytes treated with the PPARalpha agonist Wy14643 for 6 or 24 h (in vitro), mouse precision cut liver slices treated with Wy14643 for 24 h (ex vivo), and livers of wild type and Ppara knockout mice treated with Wy14643 for 6 h or 5 days (in vivo). pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus