Title : A PREVIOUSLY UNKNOWN UNIQUE CHALLENGE FOR INHIBITORS OF SYK ATP-BINDING SITE: ROLE OF SYK AS A CELL CYCLE CHECKPOINT REGULATOR.

Pub. Date : 2014 Nov 1

PMID : 25506060






2 Functional Relationships(s)
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1 SYK depletion by RNA interference or treatment with the chemical SYK inhibitor prevented nocodazole-treated human cell lines from activating the G2 checkpoint via CDC25C S216-phoshorylation and resulted in polyploidy. Nocodazole spleen associated tyrosine kinase Homo sapiens
2 SYK depletion by RNA interference or treatment with the chemical SYK inhibitor prevented nocodazole-treated human cell lines from activating the G2 checkpoint via CDC25C S216-phoshorylation and resulted in polyploidy. Nocodazole spleen associated tyrosine kinase Homo sapiens