Title : Janus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL.

Pub. Date : 2015 Feb 26

PMID : 25499760






1 Functional Relationships(s)
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1 Despite major advances in the treatment of this highly aggressive disease with potent inhibitors of the BCR-ABL kinase such as dasatinib, patients in remission frequently relapse due to persistent minimal residual disease possibly supported, at least in part, by salutary cytokine-driven signaling within the hematopoietic microenvironment. Dasatinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens