Title : Ceftriaxone prevents and reverses behavioral and neuronal deficits in an MPTP-induced animal model of Parkinson's disease dementia.

Pub. Date : 2015 Apr

PMID : 25499022






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Ceftriaxone increases expression of glutamate transporter 1 (GLT-1) and affords neuroprotection. Ceftriaxone solute carrier family 1 member 2 Rattus norvegicus
2 Ceftriaxone increases expression of glutamate transporter 1 (GLT-1) and affords neuroprotection. Ceftriaxone solute carrier family 1 member 2 Rattus norvegicus
3 Increased GLT-1 expression and its co-localization with astrocytes were observed in the striatum and hippocampus in the ceftriaxone-treated animals. Ceftriaxone solute carrier family 1 member 2 Rattus norvegicus
4 To our knowledge, this is the first study showing a relationship between ceftriaxone-induced GLT-1 expression, neuroprotection, and improved cognition in a PD rat model. Ceftriaxone solute carrier family 1 member 2 Rattus norvegicus