Title : JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death.

Pub. Date : 2015 Feb 3

PMID : 25496994






5 Functional Relationships(s)
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1 JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death. Rotenone mitogen-activated protein kinase 8 Homo sapiens
2 Furthermore, the c-Jun N-terminal protein kinase (JNK) is required for rotenone-induced dopamine neuron death. Rotenone mitogen-activated protein kinase 8 Homo sapiens
3 Furthermore, the c-Jun N-terminal protein kinase (JNK) is required for rotenone-induced dopamine neuron death. Rotenone mitogen-activated protein kinase 8 Homo sapiens
4 Treatment with taxol, a microtubule stabilizing agent, attenuates rotenone-induced phosphorylation and presumably activation of JNK. Rotenone mitogen-activated protein kinase 8 Homo sapiens
5 This suggests that JNK is activated by microtubule destabilization upon rotenone exposure. Rotenone mitogen-activated protein kinase 8 Homo sapiens