Pub. Date : 1989 Jun 19
PMID : 2549462
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ICS 205-930, a selective and potent 5-HT3 receptor antagonist applied either systemically, or locally into the ventral tegmental area, antagonized the stimulation of dopamine release in the nucleus accumbens, induced by the subcutaneous administration of morphine. | Dopamine | 5-hydroxytryptamine receptor 3A | Rattus norvegicus |
| 2 | Since stimulation of dopamine release in the nucleus accumbens is a prerequisite for the expression of the rewarding properties of morphine, its suppression by ICS 205-930 suggests a possible application of 5-HT3 receptor antagonists in the treatment of addiction. | Dopamine | 5-hydroxytryptamine receptor 3A | Rattus norvegicus |