Pub. Date : 2014 Dec 9
PMID : 25492967
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The kinase activity of Lck requires both the phosphorylation of an activating tyrosine residue and the dephosphorylation of an inhibitory tyrosine residue. | Tyrosine | LCK proto-oncogene, Src family tyrosine kinase | Homo sapiens |
| 2 | The kinase activity of Lck requires both the phosphorylation of an activating tyrosine residue and the dephosphorylation of an inhibitory tyrosine residue. | Tyrosine | LCK proto-oncogene, Src family tyrosine kinase | Homo sapiens |
| 3 | We found that a third conserved tyrosine phosphorylation site (Tyr(192)) within the SH2 domain of Lck was required for proper T cell activation and formation of cell-cell conjugates between T cells and antigen-presenting cells. | Tyrosine | LCK proto-oncogene, Src family tyrosine kinase | Homo sapiens |
| 4 | We found that a third conserved tyrosine phosphorylation site (Tyr(192)) within the SH2 domain of Lck was required for proper T cell activation and formation of cell-cell conjugates between T cells and antigen-presenting cells. | Tyrosine | LCK proto-oncogene, Src family tyrosine kinase | Homo sapiens |
| 5 | Through phosphopeptide arrays and biochemical assays, we identified several regulators of the actin cytoskeleton that preferentially bound to Lck phosphorylated at Tyr(192) compared to Lck that was not phosphorylated at this site. | Tyrosine | LCK proto-oncogene, Src family tyrosine kinase | Homo sapiens |
| 6 | Two of these phosphorylation-dependent binding partners, the kinase Itk (interleukin-2-inducible Tec kinase) and the adaptor protein TSAd (T cell-specific adaptor), promoted the TCR-dependent phosphorylation of Lck at Tyr(192). | Tyrosine | LCK proto-oncogene, Src family tyrosine kinase | Homo sapiens |