Title : Amiloride lowers blood pressure and attenuates urine plasminogen activation in patients with treatment-resistant hypertension.

Pub. Date : 2014 Dec

PMID : 25492830






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Amiloride, an ENaC inhibitor, inhibits urokinase-type plasminogen activator. Amiloride plasminogen activator, urokinase Homo sapiens
2 We hypothesized that amiloride (1) reduces blood pressure (BP); (2) attenuates plasminogen-to-plasmin activation; and (3) inhibits urine urokinase-type plasminogen activator in patients with resistant hypertension and type 2 diabetes mellitus (T2DM).In an open-label, non-randomized, 8-week intervention study, a cohort (n = 80) of patients with resistant hypertension and T2DM were included. Amiloride plasminogen activator, urokinase Homo sapiens