Pub. Date : 2015 Feb
PMID : 25487141
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Association between interleukin-18 promoter variants and tacrolimus pharmacokinetics in Chinese renal transplant patients. | Tacrolimus | interleukin 18 | Homo sapiens |
| 2 | This study aimed to assess the potential influence of two functional single nucleotide polymorphisms (SNPs) in the IL-18 promoter region on the tacrolimus pharmacokinetics in Chinese renal transplant patients. | Tacrolimus | interleukin 18 | Homo sapiens |
| 3 | RESULTS: The tacrolimus C/D ratio was significantly associated with the IL-18 rs1946518 gene polymorphism in the first month after transplantation (P = 0.0225). | Tacrolimus | interleukin 18 | Homo sapiens |
| 4 | In a simple linear regression model, age, hemoglobin (Hb), CYP3A5 gene polymorphisms, and IL-18 A-607C gene polymorphisms were associated with log-transformed tacrolimus C/D ratios (P < 0.05). | Tacrolimus | interleukin 18 | Homo sapiens |
| 5 | CONCLUSION: Our findings suggest that a combined analysis of CYP3A5 and IL-18 promoter polymorphisms may help clinicians develop individualized tacrolimus treatment, which is based on determining CYP3A5 genotype. | Tacrolimus | interleukin 18 | Homo sapiens |