Title : Phosphorylation of ribosomal protein S6 kinase 1 at Thr421/Ser424 and dephosphorylation at Thr389 regulates SP600125-induced polyploidization of megakaryocytic cell lines.

Pub. Date : 2014

PMID : 25486532






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The polyploidization was partially blocked by H-89, a cAMP-dependent protein kinase (PKA) inhibitor, through direct binding to S6K1, leading to dephosphorylation at Thr421/Ser424 and phosphorylation at Thr389, independent of PKA. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide ribosomal protein S6 kinase B1 Homo sapiens