Title : DNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study.

Pub. Date : 2015 Jan 20

PMID : 25460508






1 Functional Relationships(s)
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1 Using a methylation microarray, we identified promoter hypermethylation of FHIT (fragile histidine triad) in radioresistant OML1-R cells, established from hypo-fractionated irradiation of parental OML1 radiosensitive oral cancer cells. Histidine fragile histidine triad diadenosine triphosphatase Homo sapiens