Title : Randomized trial to evaluate azithromycin's effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis.

Pub. Date : 2015 May

PMID : 25458910






4 Functional Relationships(s)
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1 Randomized trial to evaluate azithromycin"s effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis. Azithromycin C-X-C motif chemokine ligand 8 Homo sapiens
2 OBJECTIVES: We sought to investigate whether azithromycin treatment during RSV bronchiolitis reduces serum and nasal lavage IL-8 levels and the occurrence of postbronchiolitis recurrent wheezing. Azithromycin C-X-C motif chemokine ligand 8 Homo sapiens
3 RESULTS: Compared with placebo, azithromycin treatment did not reduce serum IL-8 levels at day 8 (P = .6) but resulted in a greater decrease in nasal lavage fluid IL-8 levels by day 15 (P = .03). Azithromycin C-X-C motif chemokine ligand 8 Homo sapiens
4 CONCLUSION: In this proof-of-concept study azithromycin treatment during RSV bronchiolitis reduced upper airway IL-8 levels, prolonged the time to the third wheezing episode, and reduced overall respiratory morbidity over the subsequent year. Azithromycin C-X-C motif chemokine ligand 8 Homo sapiens