Pub. Date : 2015 May
PMID : 25458910
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Randomized trial to evaluate azithromycin"s effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis. | Azithromycin | C-X-C motif chemokine ligand 8 | Homo sapiens |
2 | OBJECTIVES: We sought to investigate whether azithromycin treatment during RSV bronchiolitis reduces serum and nasal lavage IL-8 levels and the occurrence of postbronchiolitis recurrent wheezing. | Azithromycin | C-X-C motif chemokine ligand 8 | Homo sapiens |
3 | RESULTS: Compared with placebo, azithromycin treatment did not reduce serum IL-8 levels at day 8 (P = .6) but resulted in a greater decrease in nasal lavage fluid IL-8 levels by day 15 (P = .03). | Azithromycin | C-X-C motif chemokine ligand 8 | Homo sapiens |
4 | CONCLUSION: In this proof-of-concept study azithromycin treatment during RSV bronchiolitis reduced upper airway IL-8 levels, prolonged the time to the third wheezing episode, and reduced overall respiratory morbidity over the subsequent year. | Azithromycin | C-X-C motif chemokine ligand 8 | Homo sapiens |