Title : Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques.

Pub. Date : 2015 Jan 1

PMID : 25452565






2 Functional Relationships(s)
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1 Decreased SIRT1 expression was associated with constitutively enhanced expression of the transcriptionally active form of the p65 (acetylated on lysine 310) subunit of NF-kappaB exclusively in the LPL compartment. Lysine sirtuin 1 Homo sapiens
2 Our results point to a possible mechanism where the normal immunosuppressive function of SIRT1 is inhibited by elevated miR-34a expression resulting in constitutive activation of acetylated p65 (lysine 310). Lysine sirtuin 1 Homo sapiens