Pub. Date : 2015 Jun 5
PMID : 25451587
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nrf2-mediated adaptive response to methyl glyoxal in HepG2 cells involves the induction of AKR7A2. | Pyruvaldehyde | aldo-keto reductase family 7 member A2 | Homo sapiens |
| 2 | We have shown that treating HepG2 cells with sub-lethal concentrations of MG increases the level of NADPH:quinone oxidoreductase (NQO1) mRNA by 4.5-fold, AKR1C3 mRNA by 14-fold and AKR7A2 mRNA by 4-fold. | Pyruvaldehyde | aldo-keto reductase family 7 member A2 | Homo sapiens |
| 3 | Levels of AKR7A2 protein are increased by 2.1- and 1.8-fold following 9h and 24h exposure of cells to 50 muM MG. | Pyruvaldehyde | aldo-keto reductase family 7 member A2 | Homo sapiens |
| 4 | Knockdown of AKR7A2 in HepG2 shows that AKR7A2 is responsible for up to 50% of the protection against MG toxicity in HepG2 cells. | Pyruvaldehyde | aldo-keto reductase family 7 member A2 | Homo sapiens |
| 5 | Knockdown of AKR7A2 in HepG2 shows that AKR7A2 is responsible for up to 50% of the protection against MG toxicity in HepG2 cells. | Pyruvaldehyde | aldo-keto reductase family 7 member A2 | Homo sapiens |
| 6 | In conclusion, these findings indicate that protective enzymes are significantly up-regulated in response to low concentrations of MG in HepG2 cells and that AKR7A2 contributes to protection against MG-induced toxicity. | Pyruvaldehyde | aldo-keto reductase family 7 member A2 | Homo sapiens |