| Protein Name | aldo-keto reductase family 7 member A2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 8574 |
| Gene Symbol | AKR7A2 |
| UniProt | O43488 (ARK72_HUMAN), V9HWA2 (V9HWA2_HUMAN), B4DZX4 (B4DZX4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
68
Total Number of Articles : 44 |
Description |
aldo-keto reductase family 7 member A2 |
| Gene Summary |
The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| synonyms |
|
| Properties | |