Title : Angiotensin II induces mitochondrial oxidative stress and mtDNA damage in osteoblasts by inhibiting SIRT1–FoxO3a–MnSOD pathway.

Pub. Date : 2014 Dec 5

PMID : 25450701






1 Functional Relationships(s)
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1 Finally, we show that SRT3025 (Sirt1 activator) and Mn (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP, a MnSOD mimetics) can markedly reduce mitochondrial oxidative stress and mtDNA damage. manganese(III)-tetrakis(4-benzoic acid)porphyrin superoxide dismutase 2 Homo sapiens