Title : Assessment of the drug interaction potential and single- and repeat-dose pharmacokinetics of the BRAF inhibitor dabrafenib.

Pub. Date : 2015 Apr

PMID : 25449654






1 Functional Relationships(s)
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1 The induction of CYP2C9 by dabrafenib using S-warfarin as a probe and the effects of a CYP3A inhibitor (ketoconazole) and a CYP2C8 inhibitor (gemfibrozil) on dabrafenib pharmacokinetics were evaluated in patients with BRAF V600 mutation-positive tumors. dabrafenib cytochrome P450 family 2 subfamily C member 9 Homo sapiens