Title : Antitumor and antimetastatic actions of dihydroxycoumarins (esculetin or fraxetin) through the inhibition of M2 macrophage differentiation in tumor-associated macrophages and/or G1 arrest in tumor cells.

Pub. Date : 2015 Jan 5

PMID : 25445053






3 Functional Relationships(s)
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1 Esculetin inhibited the expressions of cyclin D1, cyclin-dependent kinase (CDK) 4 and matrix metalloproteinase (MMP)-2, and production of both transforming growth factor (TGF)-beta1 and vascular endothelial growth factor (VEGF) in LM8 cells. esculetin transforming growth factor, beta 1 Mus musculus
2 These results suggested that the antitumor and antimetastatic actions of esculetin may be partly attributed to G1 arrest by the inhibition of cyclin D1 and CDK4 expression, while its antiangiogenic action may have been due to the inhibition of MMP-2 expression and TGF-beta1 and VEGF productions at tumor sites. esculetin transforming growth factor, beta 1 Mus musculus
3 Esculetin (10-100muM) and fraxetin (50-100muM) inhibited the production of interleukin (IL)-10, monocyte chemoattractant protein (MCP)-1, and TGF-beta1 during the differentiation of M2 macrophages by reducing the phosphorylation of Stat 3 without affecting its expression. esculetin transforming growth factor, beta 1 Mus musculus