Title : Ire1 has distinct catalytic mechanisms for XBP1/HAC1 splicing and RIDD.

Pub. Date : 2014 Nov 6

PMID : 25437541






2 Functional Relationships(s)
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1 Using an IRE1 RNase inhibitor, STF-083010, selective inhibition of XBP1 splicing indicates that XBP1 promotes cell survival, whereas RIDD leads to cell death, revealing modulation of IRE1 activities as a drug-development strategy. STF 083010 X-box binding protein 1 Homo sapiens
2 Using an IRE1 RNase inhibitor, STF-083010, selective inhibition of XBP1 splicing indicates that XBP1 promotes cell survival, whereas RIDD leads to cell death, revealing modulation of IRE1 activities as a drug-development strategy. STF 083010 X-box binding protein 1 Homo sapiens