Title : Change in pharmacokinetic behavior of intravenously administered midazolam due to increased CYP3A2 expression in rats treated with menthol.

Pub. Date : 2015 Apr

PMID : 25430017






2 Functional Relationships(s)
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1 Change in pharmacokinetic behavior of intravenously administered midazolam due to increased CYP3A2 expression in rats treated with menthol. Midazolam cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
2 These results indicate that menthol enhanced the elimination clearance of midazolam by inducing hepatic CYP3A2 and that careful attention should be paid when menthol is ingested in combination with drugs that act as substrates for CYP3A. Midazolam cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus