Title : Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats.

Pub. Date : 2014 Nov 25

PMID : 25422948






1 Functional Relationships(s)
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1 EGCG significantly inhibited the expression of pro-inflammatory mediators and matrix metalloproteinases in vitro, as well as radiculopathic pain in vivo, most probably by modulation of the activity of IRAK-1 and its downstream effectors p38, JNK and NF-kappaB. epigallocatechin gallate mitogen-activated protein kinase 8 Rattus norvegicus