Pub. Date : 2015 Feb
PMID : 25422161
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | eIF4E inhibition in MM cells [bone marrow (BM), lines] by siRNA and/or the anti-viral drug and competitive eIF4E inhibitor ribavirin (RBV) deleteriously affected MM cells in a similar manner to the overexpression of tetraspanins. | Ribavirin | eukaryotic translation initiation factor 4E | Homo sapiens |
| 2 | eIF4E inhibition in MM cells [bone marrow (BM), lines] by siRNA and/or the anti-viral drug and competitive eIF4E inhibitor ribavirin (RBV) deleteriously affected MM cells in a similar manner to the overexpression of tetraspanins. | Ribavirin | eukaryotic translation initiation factor 4E | Homo sapiens |
| 3 | eIF4E inhibition in MM cells [bone marrow (BM), lines] by siRNA and/or the anti-viral drug and competitive eIF4E inhibitor ribavirin (RBV) deleteriously affected MM cells in a similar manner to the overexpression of tetraspanins. | Ribavirin | eukaryotic translation initiation factor 4E | Homo sapiens |
| 4 | eIF4E inhibition in MM cells [bone marrow (BM), lines] by siRNA and/or the anti-viral drug and competitive eIF4E inhibitor ribavirin (RBV) deleteriously affected MM cells in a similar manner to the overexpression of tetraspanins. | Ribavirin | eukaryotic translation initiation factor 4E | Homo sapiens |
| 5 | Our results demonstrate that breach of proteostasis via eIF4E inhibition is an attractive therapeutic approach that may be relatively easily achieved by employing RBV, making this strategy readily translatable into the clinic. | Ribavirin | eukaryotic translation initiation factor 4E | Homo sapiens |