Title : Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain.

Pub. Date : 2014 Dec 26

PMID : 25420090






2 Functional Relationships(s)
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1 The discovery and synthesis of a new series of pyrimidines as potent sigma-1 receptor (sigma1R) antagonists, associated with pharmacological antineuropathic pain activity, are the focus of this article. Pyrimidines sigma non-opioid intracellular receptor 1 Rattus norvegicus
2 The discovery and synthesis of a new series of pyrimidines as potent sigma-1 receptor (sigma1R) antagonists, associated with pharmacological antineuropathic pain activity, are the focus of this article. Pyrimidines sigma non-opioid intracellular receptor 1 Rattus norvegicus