Title : Possible role of resveratrol targeting estradiol and neprilysin pathways in lipopolysaccharide model of Alzheimer disease.

Pub. Date : 2015

PMID : 25416980






2 Functional Relationships(s)
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1 Moreover RSV was able to significantly increase both the estradiol level and NEP level and that may have a great role to decrease Abeta deposition as it has been confirmed that there is a link between NEP and estradiol level; by upregulation of estradiol level this consequently leads to increase in the level of NEP level, and by increasing the NEP level in brain, this lead to decrease in Abeta deposition and enhancing its degradation by NEP. Resveratrol amyloid beta (A4) precursor protein Mus musculus
2 Moreover RSV was able to significantly increase both the estradiol level and NEP level and that may have a great role to decrease Abeta deposition as it has been confirmed that there is a link between NEP and estradiol level; by upregulation of estradiol level this consequently leads to increase in the level of NEP level, and by increasing the NEP level in brain, this lead to decrease in Abeta deposition and enhancing its degradation by NEP. Resveratrol amyloid beta (A4) precursor protein Mus musculus