Title : Downregulation of hTERT: an important As2O3 induced mechanism of apoptosis in myelodysplastic syndrome.

Pub. Date : 2014

PMID : 25415199

2 Functional Relationships(s)
Compound Name
Protein Name
1 As2O3 induced this two cell lines apoptosis via activation of caspase-3/8 and cleavage of poly (ADP-ribose) polymerase (PARP), a DNA repair enzyme. Arsenic Trioxide caspase 3 Homo sapiens
2 Our findings suggest that As2O3 may induce apoptosis in MUTZ-1 and SKM-1 cells by two independent pathways: first, by activation of caspase-3/8 and PARP; and second, by inhibition of NF-kappaB activity, which results in downregulation of hTERT expression. Arsenic Trioxide caspase 3 Homo sapiens