Pub. Date : 2014
PMID : 25415199
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | As2O3 induced this two cell lines apoptosis via activation of caspase-3/8 and cleavage of poly (ADP-ribose) polymerase (PARP), a DNA repair enzyme. | Arsenic Trioxide | caspase 3 | Homo sapiens |
| 2 | Our findings suggest that As2O3 may induce apoptosis in MUTZ-1 and SKM-1 cells by two independent pathways: first, by activation of caspase-3/8 and PARP; and second, by inhibition of NF-kappaB activity, which results in downregulation of hTERT expression. | Arsenic Trioxide | caspase 3 | Homo sapiens |