Title : Retinoic acid receptor-β gene reexpression and biological activity in SHI-1 cells after combined treatment with 5-aza-2'-deoxycytidine and all-trans retinoic acid.

Pub. Date : 2015

PMID : 25413479






3 Functional Relationships(s)
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Protein Name
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1 Retinoic acid receptor-beta gene reexpression and biological activity in SHI-1 cells after combined treatment with 5-aza-2"-deoxycytidine and all-trans retinoic acid. Decitabine retinoic acid receptor beta Homo sapiens
2 BACKGROUND: This study was conducted to determine the antineoplastic activities of 5-aza-2"-deoxycytidine (decitabine; DAC) and all-trans retinoic acid (ATRA), administered either alone or in combination, on in vitro cultured SHI-1 cells as well as their effects on the expression of the tumor suppressor gene p16(INK4a) (p16) and the retinoic acid receptor (RAR)-beta. Decitabine retinoic acid receptor beta Homo sapiens
3 DAC, either alone or in combination with ATRA, induced demethylation of the genes p16 and RAR-beta, whereas ATRA alone had no effect on methylation. Decitabine retinoic acid receptor beta Homo sapiens