Title : IFN-gamma and LPS overcome glucocorticoid inhibition of priming for superoxide release in human monocytes. Evidence that secretion of IL-1 and tumor necrosis factor-alpha is not essential for monocyte priming.

Pub. Date : 1989 Jun 1

PMID : 2541203






4 Functional Relationships(s)
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1 IFN-gamma and LPS overcome glucocorticoid inhibition of priming for superoxide release in human monocytes. Superoxides interferon gamma Homo sapiens
2 Monocytes incubated with either IFN-gamma or LPS became "primed" and released greater amounts of O2- in response to stimuli. Superoxides interferon gamma Homo sapiens
3 When glucocorticoids were co-incubated with IFN-gamma or LPS, the effect of hydrocortisone and other active steroids was blocked, and the monocytes released high O2-. Superoxides interferon gamma Homo sapiens
4 However, when monocytes were preincubated with hydrocortisone for 24 h before addition of IFN-gamma or LPS, priming for enhanced O2- production by LPS was partially inhibited whereas there was no effect on IFN-gamma priming. Superoxides interferon gamma Homo sapiens