Pub. Date : 2015 Apr
PMID : 25411027
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sequential treatment with aurora B inhibitors enhances cisplatin-mediated apoptosis via c-Myc. | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | Thus, our report reveals for the first time that sequential treatment of Aurora B inhibitors and cisplatin is essential to inhibit ovarian carcinoma by inducing polyploidy and downregulating c-Myc and that c-Myc is identified as a predictive biomarker to select cells responsive to chemotherapeutical combinations targeting Aurora B. | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | Thus, our report reveals for the first time that sequential treatment of Aurora B inhibitors and cisplatin is essential to inhibit ovarian carcinoma by inducing polyploidy and downregulating c-Myc and that c-Myc is identified as a predictive biomarker to select cells responsive to chemotherapeutical combinations targeting Aurora B. | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 4 | The synergy of Aurora B inhibitor with cisplatin is dependent on c-Myc expression. | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 5 | c-Myc-dependent induction of polyploidy sensitizes cells to cisplatin. | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |