Title : In vitro evaluation of a tetrahydroisoquinoline derivative as a steroid sulfatase inhibitor and a selective estrogen receptor modulator.

Pub. Date : 2015 Feb

PMID : 25410727






1 Functional Relationships(s)
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1 Saos-2 cell proliferation was increased by 21 % following 8-EO-14 addition (1 muM), and 8-EO-14 induced ALP activity (31 % increase at 0.1 nM) via estrogen receptor alpha (ERalpha) similarly to the SERM raloxifene. Raloxifene Hydrochloride alkaline phosphatase, placental Homo sapiens