Title : Enantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]octanes as Selective α4β2-nAChR Ligands.

Pub. Date : 2014 Nov 13

PMID : 25408831






2 Functional Relationships(s)
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1 Structure-activity relationship studies revealed that incorporation of a cyclopropane-containing side chain at the 5-position of the pyridine ring provides ligands with improved subtype selectivity for nAChR beta2 subunit-containing nAChR subtypes (beta2*-nAChRs) over beta4*-nAChRs compared to the parent compound 4. pyridine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 Structure-activity relationship studies revealed that incorporation of a cyclopropane-containing side chain at the 5-position of the pyridine ring provides ligands with improved subtype selectivity for nAChR beta2 subunit-containing nAChR subtypes (beta2*-nAChRs) over beta4*-nAChRs compared to the parent compound 4. pyridine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus