Title : Knockdown of Bcl-xL enhances growth-inhibiting and apoptosis-inducing effects of resveratrol and clofarabine in malignant mesothelioma H-2452 cells.

Pub. Date : 2014 Nov

PMID : 25408576






2 Functional Relationships(s)
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1 Resveratrol and clofarabine decreased Mcl-1 protein levels but had little effect on Bcl-xL levels. Clofarabine MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 Collectively, our data represent that the efficacy of resveratrol and clofarabine for apoptosis induction was substantially enhanced by Bcl-xL-lowering strategy in which the simultaneous targeting of Mcl-1 and Bcl-xL could be a more effective strategy for treating malignant mesothelioma. Clofarabine MCL1 apoptosis regulator, BCL2 family member Homo sapiens