Title : N-3 polyunsaturated fatty acids decrease levels of doxorubicin-induced reactive oxygen species in cardiomyocytes -- involvement of uncoupling protein UCP2.

Pub. Date : 2014 Nov 18

PMID : 25407516






4 Functional Relationships(s)
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1 N-3 polyunsaturated fatty acids decrease levels of doxorubicin-induced reactive oxygen species in cardiomyocytes -- involvement of uncoupling protein UCP2. Doxorubicin uncoupling protein 2 Homo sapiens
2 Pretreatment with 100 muM EPA or 50 muM DHA prevented the DOX-induced decrease in UCP2 mRNA and protein levels, but these effects were not seen with EPA or DHA and DOX cotreatment. Doxorubicin uncoupling protein 2 Homo sapiens
3 CONCLUSION: EPA or DHA pre-treatment inhibits the DOX-induced decrease in UCP2 expression, increase in ROS production, and subsequent mitochondrial membrane potential change that contribute to the cardiotoxicity of DOX. Doxorubicin uncoupling protein 2 Homo sapiens
4 CONCLUSION: EPA or DHA pre-treatment inhibits the DOX-induced decrease in UCP2 expression, increase in ROS production, and subsequent mitochondrial membrane potential change that contribute to the cardiotoxicity of DOX. Doxorubicin uncoupling protein 2 Homo sapiens