Pub. Date : 2014 Nov 13
PMID : 25401399
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Synthetic genistein glycosides inhibiting EGFR phosphorylation enhance the effect of radiation in HCT 116 colon cancer cells. | Genistein | epidermal growth factor receptor | Homo sapiens |
| 2 | The need to find new EGFR inhibitors for use in combination with radiotherapy in the treatment of solid tumors has drawn our attention to compounds derived from genistein, a natural isoflavonoid. | Genistein | epidermal growth factor receptor | Homo sapiens |
| 3 | Genistein derivatives inhibited clonogenic growth of HCT 116 cancer cells additively or synergistically when used in combination with ionizing radiation, and decreased EGFR activation. | Genistein | epidermal growth factor receptor | Homo sapiens |
| 4 | Our preclinical evaluation of genistein-derived EGFR inhibitors suggests that these compounds are much more potent sensitizers of cells to radiation than the parent isoflavonoid, genistein and indicate that these compounds may be useful in the treatment of colon cancer with radiation therapy. | Genistein | epidermal growth factor receptor | Homo sapiens |