Pub. Date : 2015 Jan 15
PMID : 25398452
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Whole-exome sequencing reveals defective CYP3A4 variants predictive of paclitaxel dose-limiting neuropathy. | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Relative to CYP3A4 wild-type patients, those carrying CYP3A4 defective variants had more severe neuropathy (2- and 1.3-fold higher risk of neuropathy for loss-of-function and missense variants, respectively, P = 0.045) and higher probability of neuropathy-induced paclitaxel treatment modifications (7- and 3-fold higher risk for loss-of-function and missense variants, respectively, P = 5.9 x 10(-5)). | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | CYP3A4 defective variants may provide a basis for paclitaxel treatment individualization. | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |