Pub. Date : 2014 Nov 25
PMID : 25385584
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We sought to quantitate precisely the propensity of commonly consumed NSAIDs:ibuprofen, naproxen, and celecoxib:to cause a drug-drug interaction with aspirin in vivo by measuring the target engagement of aspirin directly by MS. We developed a novel assay of cyclooxygenase-1 (COX-1) acetylation in platelets isolated from volunteers who were administered aspirin and used conventional and microfluidic assays to evaluate platelet function. | Ibuprofen | prostaglandin-endoperoxide synthase 1 | Homo sapiens |
| 2 | We sought to quantitate precisely the propensity of commonly consumed NSAIDs:ibuprofen, naproxen, and celecoxib:to cause a drug-drug interaction with aspirin in vivo by measuring the target engagement of aspirin directly by MS. We developed a novel assay of cyclooxygenase-1 (COX-1) acetylation in platelets isolated from volunteers who were administered aspirin and used conventional and microfluidic assays to evaluate platelet function. | Ibuprofen | prostaglandin-endoperoxide synthase 1 | Homo sapiens |