Pub. Date : 2015 Jan
PMID : 25385104
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lycopene attenuates colistin-induced nephrotoxicity in mice via activation of the Nrf2/HO-1 pathway. | Lycopene | heme oxygenase 1 | Mus musculus |
| 2 | Lycopene treatment, especially in the colistin plus lycopene (20 mg/kg) group, significantly downregulated the expression of NF-kappaB mRNA (P < 0.01) but upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and HO-1 mRNA (both P < 0.01) in the kidney compared with the results seen with the colistin group. | Lycopene | heme oxygenase 1 | Mus musculus |
| 3 | This effect may be attributed to the antioxidative property of lycopene and its ability to activate the Nrf2/HO-1 pathway. | Lycopene | heme oxygenase 1 | Mus musculus |