Title : STIM1 overexpression promotes colorectal cancer progression, cell motility and COX-2 expression.

Pub. Date : 2015 Aug 13

PMID : 25381814






2 Functional Relationships(s)
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1 Importantly, ectopically expressed COX-2 or exogenous PGE2 were able to rescue migration defect in STIM1 knockdown CRC cells, and inhibition of COX-2 with ibuprofen and indomethacin abrogated STIM1-mediated CRC cell motility. Indomethacin prostaglandin-endoperoxide synthase 2 Homo sapiens
2 Importantly, ectopically expressed COX-2 or exogenous PGE2 were able to rescue migration defect in STIM1 knockdown CRC cells, and inhibition of COX-2 with ibuprofen and indomethacin abrogated STIM1-mediated CRC cell motility. Indomethacin prostaglandin-endoperoxide synthase 2 Homo sapiens