Title : Nicotine-induced upregulation of VCAM-1, MMP-2, and MMP-9 through the α7-nAChR-JNK pathway in RAW264.7 and MOVAS cells.

Pub. Date : 2015 Jan

PMID : 25381636






1 Functional Relationships(s)
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1 When cells were pretreated with either SP600125 (JNK inhibitor) or PNU-282987 (alpha7-nAChR agonist) prior to nicotine exposure, the nicotine-induced upregulation of VCAM-1, MMP-2, MMP-9, and p-JNK was suppressed, with a joint treatment producing a more significant inhibitory effect. PNU-282987 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus