Pub. Date : 2014 Oct
PMID : 25379021
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation. | AZD 6244 | ribosomal protein S6 kinase B1 | Homo sapiens |
| 2 | Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation. | AZD 6244 | ribosomal protein S6 kinase B1 | Homo sapiens |
| 3 | Surprisingly, Selumetinib was able to inhibit phosphorylation of p70 S6 kinase (p70S6K) and its downstream target ribosomal protein S6 (RPS6) in sensitive cell lines. | AZD 6244 | ribosomal protein S6 kinase B1 | Homo sapiens |
| 4 | Surprisingly, Selumetinib was able to inhibit phosphorylation of p70 S6 kinase (p70S6K) and its downstream target ribosomal protein S6 (RPS6) in sensitive cell lines. | AZD 6244 | ribosomal protein S6 kinase B1 | Homo sapiens |
| 5 | Pharmacological inhibition of p70S6K using the PI3K/mTOR inhibitor NVP-BEZ235, the specific mTOR inhibitor Rapamycin and the specific p70S6K inhibitor PF-4708671 potentiated Selumetinib effects in resistant cells. | AZD 6244 | ribosomal protein S6 kinase B1 | Homo sapiens |
| 6 | In addition, biological inhibition of p70S6K using siRNA rendered responsiveness to Selumetinib in resistant cell lines. | AZD 6244 | ribosomal protein S6 kinase B1 | Homo sapiens |
| 7 | We can conclude that p70S6K and its downstream target RPS6 are potential biomarkers of resistance to Selumetinib in colorectal cancer. | AZD 6244 | ribosomal protein S6 kinase B1 | Homo sapiens |