Pub. Date : 2014
PMID : 25364233
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of the Kelch-like erythroid cell-derived protein with CNC homology-associated protein 1 (Keap1)/the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in the therapeutic activities of CDDO-Me will be discussed. | bardoxolone methyl | kelch like ECH associated protein 1 | Homo sapiens |
| 2 | CDDO-Me contains alpha,beta-unsaturated carbonyl groups on rings A and C that can generate reversible adducts with the thiol groups of Cys residues in target proteins such as Keap1 and IkappaB kinase. | bardoxolone methyl | kelch like ECH associated protein 1 | Homo sapiens |