Title : Injection of corticotropin-releasing hormone into the amygdala aggravates visceral nociception and induces noradrenaline release in rats.

Pub. Date : 2015 Jan

PMID : 25359531






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1 Injection of corticotropin-releasing hormone into the amygdala aggravates visceral nociception and induces noradrenaline release in rats. Norepinephrine corticotropin releasing hormone Rattus norvegicus
2 Here, we verified the hypothesis that CRH in the CeA sensitizes visceral nociception via CRH-R1 with release of noradrenaline, dopamine, and serotonin (5-HT) in the CeA. Norepinephrine corticotropin releasing hormone Rattus norvegicus
3 Noradrenaline in the CeA was increased by CRD, further increased by CRH, and inhibited by CRH-R1 antagonist. Norepinephrine corticotropin releasing hormone Rattus norvegicus
4 CONCLUSIONS & INFERENCES: These results suggest that CRH in the CeA sensitizes visceral nociception via CRH-R1 with release of noradrenaline. Norepinephrine corticotropin releasing hormone Rattus norvegicus