Pub. Date : 2015 Feb
PMID : 25351103
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. | YH-306 | protein tyrosine kinase 2 | Homo sapiens |
| 2 | YH-306 suppressed the activation of focal adhesion kinase (FAK), c-Src, paxillin, and phosphatidylinositol 3-kinases (PI3K), Rac1 and the expression of matrix metalloproteases (MMP) 2 and MMP9. | YH-306 | protein tyrosine kinase 2 | Homo sapiens |
| 3 | YH-306 suppressed the activation of focal adhesion kinase (FAK), c-Src, paxillin, and phosphatidylinositol 3-kinases (PI3K), Rac1 and the expression of matrix metalloproteases (MMP) 2 and MMP9. | YH-306 | protein tyrosine kinase 2 | Homo sapiens |
| 4 | Taken together, YH-306 is a candidate drug in preventing growth and metastasis of CRC by modulating FAK signalling pathway. | YH-306 | protein tyrosine kinase 2 | Homo sapiens |