Pub. Date : 2014 Oct 25
PMID : 25344679
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Western blot analysis showed that FTY720 induced cleavage of caspases 3, 8 and 9, and of PARP, in a dose-dependent manner, consistent with a substantial decrease in p-STAT3, Bcl-xL, Bcl-2, survivin, cyclin D1, cyclin E, N-cadherin, vimentin, VEGF and TWIST1. | Fingolimod Hydrochloride | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | CONCLUSIONS: These results suggest that FTY720 induces a significant decrease in p-STAT3, which inhibits proliferation and EMT of CC cells, and then induces G1 phase arrest and apoptosis. | Fingolimod Hydrochloride | signal transducer and activator of transcription 3 | Homo sapiens |