Title : JNK-NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress.

Pub. Date : 2014 Oct 23

PMID : 25341038






1 Functional Relationships(s)
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1 Concurrently, stress-activated JNK phosphorylates TAp73 at multiple serine and threonine residues, which is crucial to ablate TAp73/MDM2 complex and to promote TAp73 transcriptional function and induction of robust apoptosis. Serine mitogen-activated protein kinase 8 Homo sapiens