Pub. Date : 2014
PMID : 25332685
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexmedetomidine-induced contraction involves phosphorylation of caldesmon by JNK in endothelium-denuded rat aortas. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 2 | The effects of GF109203X (a PKC inhibitor) on DMT- or PDBu-induced JNK phosphorylation in VSMCs were assessed. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 3 | Additionally, PDBu induced caldesmon phosphorylation, and GF109203X attenuated the JNK phosphorylation induced by DMT or PDBu. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 4 | These results suggest that alpha-2 adrenoceptor-mediated, DMT-induced contraction involves caldesmon phosphorylation that is mediated by JNK phosphorylation by PKC. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |