Title : Salmeterol's extreme β2 selectivity is due to residues in both extracellular loops and transmembrane domains.

Pub. Date : 2015 Jan

PMID : 25324048






1 Functional Relationships(s)
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1 Extracellular loop 3 (and specifically amino acid K305) had the largest single effect by reducing salmeterol"s affinity for the beta2-adrenoceptor by 31-fold. Salmeterol Xinafoate adrenoceptor beta 2 Homo sapiens